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193, 152163 10.1002/aja.1001930207 [DOI] [PubMed] [Google Scholar] Donahue S., Pappas G

NSAID Interference with Aspirin's Antiplatelet Effects As illustrated in Figure 3, non-aspirin NSAIDs can interfere with aspirin's ability to gain access to its COX-1 binding site by steric interference(2 drugs can't occupy the same active site at the same time), thus reducing aspirin's antiplatelet effects when the two drug types are taken concomitantly

However, there are also cases when additional factors such as lack of sleep, poor diet, and deficiency of other vitamins like iron, folate, and others, contribute to the issue

Although these studies did not investigate the effects of urolithin A on sleep directly, they have shown that urolithin A may help mitigate the adverse effects of sleep deprivation, with potential to improve daytime function and perceived well-being in individuals with poor sleep health